Cone Photoreceptor Function Loss-3, a Novel Mouse Model of Achromatopsia Due to a Mutation inGnat2
Investigative Ophthalmology & Visual Science2006Vol. 47(11), pp. 5017–5017
Citations Over TimeTop 11% of 2006 papers
Bo Chang, Mark S. Dacey, N. L. Hawes, Peter F. Hitchcock, Ann H. Milam, Pelin Atmaca-Sönmez, Steven Nusinowitz, John R. Heckenlively
Abstract
The Gnat2(cpfl3) mutation leads to cone dysfunction and the progressive loss of cone alpha-transducin immunolabeling. Despite a poor cone ERG signal and loss of cone alpha-transducin label, the cones survive at 14 weeks as demonstrated by PNA staining. This mouse model of achromatopsia will be useful in the study of the development, pathophysiology, and treatment of achromatopsia and other cone degenerations. The gene symbol for the cpfl3 mutation has been changed to Gnat2(cpfl3).
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