Clusterin Deficiency in Eyes with Pseudoexfoliation Syndrome May Be Implicated in the Aggregation and Deposition of Pseudoexfoliative Material
Investigative Ophthalmology & Visual Science2006Vol. 47(5), pp. 1982–1982
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Matthias Zenkel, Friedrich E. Kruse, Anselm G. Ju ̈nemann, Gottfried O.H. Naumann, Ursula Schlo ̈tzer-Schrehardt
Abstract
Considering the known role of clusterin as a highly efficient extracellular chaperone, its deficiency in the anterior segment of PEX eyes may promote the stress-induced aggregation and stable deposition of the pathologic extracellular matrix product characteristic of PEX syndrome.
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