Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for Glaucoma
Investigative Ophthalmology & Visual Science2007Vol. 48(3), pp. 1191–1191
Citations Over TimeTop 10% of 2007 papers
Robert J. Wordinger, Debra L. Fleenor, Peggy E. Hellberg, Iok-Hou Pang, T. Tovar, Gulab Zode, John A. Fuller, Abbot F. Clark
Abstract
These results are consistent with the hypothesis that, in POAG, elevated expression of Gremlin by TM cells inhibits BMP-4 antagonism of TGF-beta2 and leads to increased ECM deposition and elevated IOP.
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