CTRP5 Is a Membrane-Associated and Secretory Protein in the RPE and Ciliary Body and the S163R Mutation of CTRP5 Impairs Its Secretion
Investigative Ophthalmology & Visual Science2006Vol. 47(12), pp. 5505–5505
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Md Nawajes A. Mandal, Vidyullatha Vasireddy, G. Bhanuprakash Reddy, Xiaofei Wang, Sayoko E. Moroi, Bikash R. Pattnaik, Bret A. Hughes, John R. Heckenlively, Peter F. Hitchcock, Monica M. Jablonski, Radha Ayyagari
Abstract
CTRP5, a secretory and membrane-associated protein, is localized to the lateral and apical membranes of the RPE and CB. Impaired secretion of the mutant protein may underlie the pathophysiology of L-ORD and LAZ.
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