Elevated Hydrostatic Pressure Triggers Mitochondrial Fission and Decreases Cellular ATP in Differentiated RGC-5 Cells
Investigative Ophthalmology & Visual Science2007Vol. 48(5), pp. 2145–2145
Citations Over TimeTop 10% of 2007 papers
Won‐Kyu Ju, Quan Liu, Keunyoung Kim, Jonathan G. Crowston, James D. Lindsey, Neeraj Agarwal, Mark H. Ellisman, Guy Perkins, Robert N. Weinreb
Abstract
Elevated hydrostatic pressure triggered mitochondrial fission, abnormal cristae depletion, Drp-1 translocation, and cellular ATP reduction in differentiated RGC-5 cells. Increased understanding of the molecular mechanisms that regulate the cellular response to elevated pressure including mitochondrial fission may provide new therapeutic targets for protecting RGCs from elevated hydrostatic pressure.
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