Expression, Subcellular Localization, and Regulation of Sigma Receptor in Retinal Muller Cells
Investigative Ophthalmology & Visual Science2006Vol. 47(12), pp. 5576–5576
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Guoliang Jiang, Barbara A. Mysona, Ying Dun, Jaya P. Gnana‐Prakasam, Navjotsingh Pabla, Weiguo Li, Zheng Dong, Vadivel Ganapathy, Sylvia B. Smith
Abstract
MCs express sigmaR1 and demonstrate robust sigmaR1 binding activity, which is inhibited by sigmaR1 ligands and is stimulated during oxidative stress. The potential of Müller cells to bind sigmaR1 ligands may prove beneficial in retinal degenerative diseases such as diabetic retinopathy.
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