Morphologic Characterization of Organized Extracellular Matrix Deposition by Ascorbic Acid–Stimulated Human Corneal Fibroblasts
Investigative Ophthalmology & Visual Science2007Vol. 48(9), pp. 4050–4050
Citations Over TimeTop 10% of 2007 papers
Xiaoqing Guo, Audrey E. K. Hutcheon, Suzanna A. Melotti, James D. Zieske, Vickery Trinkaus‐Randall, Jeffrey W. Ruberti
Abstract
Human keratocytes, cultured in a stable vitamin C derivative, are capable of assembling extracellular matrix, which comprises parallel arrays of ECM fibrils. The resultant constructs, which are highly cellular, are morphologically similar to the developing mammalian stroma, where organized matrix is derived. The appearance of arrays of structures on the cell membranes suggests a role in the local organization of synthesized ECM. This model could provide critical insight into the fundamental processes that govern the genesis of organized connective tissues such as the cornea and may provide a scaffolding suitable for tissue engineering a biomimetic stroma.
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