Attenuated Glial Reactions and Photoreceptor Degeneration after Retinal Detachment in Mice Deficient in Glial Fibrillary Acidic Protein and Vimentin
Investigative Ophthalmology & Visual Science2007Vol. 48(6), pp. 2760–2760
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Toru Nakazawa, Masumi Takeda, Geoffrey P. Lewis, Kin‐Sang Cho, Jianwei Jiao, Ulrika Wilhelmsson, Steven K. Fisher, Milos Pekny, Dong Feng Chen, Joan W. Miller
Abstract
The absence of GFAP and vimentin attenuates RD-induced reactive gliosis and, subsequently, limits photoreceptor degeneration. Results of this study indicate that reactive retinal glial cells contribute critically to retinal damage induced by RD and provide a new avenue for limiting photoreceptor degeneration associated with RD and other retinal diseases or damage.
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