γD-Crystallin–Associated Protein Aggregation and Lens Fiber Cell Denucleation
Investigative Ophthalmology & Visual Science2007Vol. 48(8), pp. 3719–3719
Citations Over TimeTop 15% of 2007 papers
Kaijun Wang, Catherine Cheng, Lin Li, Haiquan Liu, Qingling Huang, Chun‐hong Xia, Ke Yao, Peiqing Sun, Joseph Horwitz, Xiaohua Gong
Abstract
Mutant gammaD-V76D reduces protein solubility in the lens and forms substantial intranuclear aggregates that disrupt the denucleation process of inner lens fiber cells. Sustained fiber cell nuclei and nuclear remnants scatter light, whereas other downstream events, such as decreased connexins, presumably disrupt gap junction communication and lens homeostasis, further contributing to the cataract phenotype in mutant lenses. This work also suggests that gammaD-crystallin is one of the crucial components for the formation of cold cataracts in vivo.
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