Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ
Investigative Ophthalmology & Visual Science2007Vol. 48(6), pp. 2553–2553
Citations Over TimeTop 10% of 2007 papers
Cintia S. de Paiva, Arturo Villarreal, Rosa M. Corrales, Hassan Rahman, Victor Chang, William J. Farley, Michael E. Stern, Jérry Y. Niederkorn, De-Quan Li, Stephen C. Pflugfelder
Abstract
Conjunctival epithelial response to experimental dryness is related to the degree of CD4+ T-cell infiltration and the level of IFN-gamma production. These findings suggest that IFN-gamma plays a pivotal role in promoting conjunctival squamous metaplasia in dry eye, and they provide insight into the immune pathogenesis of keratoconjunctivitis sicca.
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