α-Aminoadipate Induces Progenitor Cell Properties of Muller Glia in Adult Mice
Investigative Ophthalmology & Visual Science2008Vol. 49(3), pp. 1142–1142
Citations Over TimeTop 10% of 2008 papers
Masumi Takeda, Akira Takamiya, Jianwei Jiao, Kin‐Sang Cho, Simon G. Trevino, Takahiko Matsuda, Dong Feng Chen
Abstract
Mature Müller glia in adult mice can be induced to dedifferentiate, migrate, and generate new retinal neurons and photoreceptor cells by alpha-aminoadipate or glutamate signaling. The results of this study suggest a novel potential strategy for treating retinal neurodegeneration, including retinitis pigmentosa and age-related macular degeneration, without transplanting exogenous cells.
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