High Susceptibility to Experimental Myopia in a Mouse Model with a Retinal ON Pathway Defect
Investigative Ophthalmology & Visual Science2008Vol. 49(2), pp. 706–706
Citations Over TimeTop 21% of 2008 papers
Machelle T. Pardue, Amanda E. Faulkner, Alcides Fernandes, Hang Yin, Frank Schaeffel, Robert W. Williams, Nikita Pozdeyev, P. Michael Iuvone
Abstract
Under normal laboratory visual conditions, only minor differences in refractive development were observed between the nob and WT mice. The largest myopic shift in the nob mice resulted after form deprivation, suggesting that visual pathways dependent on nyctalopin and/or abnormally low dopaminergic activity play a role in regulating refractive development. These findings demonstrate an interaction of genetics and environment in refractive development.
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