A Rabbit Dry Eye Model Induced by Topical Medication of a Preservative Benzalkonium Chloride
Investigative Ophthalmology & Visual Science2008Vol. 49(5), pp. 1850–1850
Citations Over TimeTop 10% of 2008 papers
Cuiju Xiong, Dong Chen, Jingbo Liu, Bingqian Liu, Naiyang Li, Yang Zhou, Xuanwei Liang, Ping Ma, Chengtian Ye, Jian Ge, Zhichong Wang
Abstract
These findings demonstrated that an ophthalmic preservative, benzalkonium chloride, induced a dry eye syndrome in rabbits with damage to the cornea and conjunctiva, decreased aqueous tear basal secretion, goblet cell loss, and MUC5AC deficiency. This rabbit model was consistent with human dry eye syndrome in both aqueous tear and mucin deficiency and may be appropriate for studying dry eye syndrome.
Related Papers
- → Immune - Goblet cell interaction in the conjunctiva(2020)89 cited
- → Goblet Cells of the Human Conjunctiva(1981)28 cited
- → Distribution and density of conjunctival goblet cells(2002)32 cited
- → The Effect of Extremely Low Frequency Magnetic Field on the Conjunctiva and Goblet Cells(2008)8 cited
- [Distribution of conjunctival goblet cells and observation of goblet cells after conjunctival autotransplantation in rabbits].(1996)