Neuroprotective Effects of Naloxone against Light-Induced Photoreceptor Degeneration through Inhibiting Retinal Microglial Activation
Investigative Ophthalmology & Visual Science2008Vol. 49(6), pp. 2589–2589
Citations Over TimeTop 10% of 2008 papers
Abstract
The activation and migration of microglia and the expression of neurotoxic factor (IL-1beta) coincide with photoreceptor apoptosis, suggesting that activated microglia play a major role in light-induced photoreceptor degeneration. Inhibiting microglial activation by naloxone significantly reduces this degeneration.
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