Angiopoietin-like 7 Secretion Is Induced by Glaucoma Stimuli and Its Concentration Is Elevated in Glaucomatous Aqueous Humor
Investigative Ophthalmology & Visual Science2008Vol. 49(8), pp. 3438–3438
Citations Over TimeTop 14% of 2008 papers
John Kuchtey, Maria E. Ka ̈llberg, Kirk N. Gelatt, Tommy A. Rinkoski, Andra ́s M. Koma`romy, Rachel W. Kuchtey
Abstract
Induction of ANGPTL7 secretion by glaucoma stimuli and increased concentration of ANGPTL7 in glaucomatous AH suggest that ANGPTL7 is overexpressed in glaucoma. Since overexpression of ANGPTL7 increases collagen expression, a potential disease mechanism, ANGPTL7 could have a pathogenic role in glaucoma, and may serve as a potential therapeutic target.
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