Mitochondrial Complex I Defect Induces ROS Release and Degeneration in Trabecular Meshwork Cells of POAG Patients: Protection by Antioxidants
Investigative Ophthalmology & Visual Science2008Vol. 49(4), pp. 1447–1447
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Yuan He, Kar Wah Leung, Yue-Hong Zhang, Shan Duan, Xiu-Feng Zhong, Ru-Zhang Jiang, Peng Zhan, Joyce Tombran‐Tink, Jian Ge
Abstract
The authors propose that a mitochondrial complex I defect is associated with the degeneration of TM cells in patients with POAG, and antioxidants and MPT inhibitors can reduce the progression of this condition.
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