Toll-like Receptor Polymorphisms and Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science2008Vol. 49(4), pp. 1652–1652
Citations Over TimeTop 10% of 2008 papers
Albert O. Edwards, Dequan Chen, Brooke L. Fridley, Katherine M. James, Yanhong Wu, Gonçalo R. Abecasis, Anand Swaroop, Mohammad Othman, Kari Branham, Sudha K. Iyengar, Theru A. Sivakumaran, Ronald Klein, Barbara E.K. Klein, Nirubol Tosakulwong
Abstract
Although borderline support for association between polymorphisms in TLR genes and AMD was reported for some cohorts, these initial observations of coding SNPs in TLR3, TLR4, and TLR7 were not replicated. TLR variants are unlikely to have a major impact on overall AMD risk, and the common variants studied were not associated with AMD.
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