AAV-Mediated Gene Therapy for Retinal Degeneration in therd10Mouse Containing a Recessive PDEβ Mutation
Investigative Ophthalmology & Visual Science2008Vol. 49(10), pp. 4278–4278
Citations Over TimeTop 10% of 2008 papers
Jijing Pang, Sanford L. Boye, Ashok Kumar, Astra Dinculescu, Wen‐Tao Deng, Jie Li, Qiuhong Li, Asha Rani, Thomas C. Foster, Bo Chang, Norman L. Hawes, Jeffrey H. Boatright, William W. Hauswirth
Abstract
These data demonstrate that P14 administration of AAV5-smCBA-PDEbeta can prevent retinal degeneration in rd10 mice, as reflected by significant structural, biochemical, electrophysiological, and behavioral preservation/restoration. These results serve as a baseline for studying long-term retinal rescue in rd10 mice.
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