Sigma-1 Receptor Regulation of Voltage-Gated Calcium Channels Involves a Direct Interaction
Investigative Ophthalmology & Visual Science2008Vol. 49(11), pp. 4993–4993
Citations Over TimeTop 11% of 2008 papers
Abstract
These results suggest that sigma-1 receptor activation can regulate calcium homeostasis and signaling in RGCs, likely by directly influencing the activity of L-type voltage-gated calcium channels. Regulation of calcium influx in RGCs by sigma-1 receptor ligands may represent in part the neuroprotective effect of sigma-1 receptors.
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