Progressive Morphological and Functional Defects in Retinas from α1 Integrin-Null Mice
Investigative Ophthalmology & Visual Science2008Vol. 49(10), pp. 4647–4647
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You‐Wei Peng, Marisa Zallocchi, Daniel T. Meehan, Duane Delimont, Bo Chang, Norman L. Hawes, Weimin Wang, Dominic Cosgrove
Abstract
Collectively, these data suggest an essential role for alpha1beta1 integrin/basement membrane interactions in the RPE in basement membrane metabolism and translocation of transducin in photoreceptors. This is the first report describing evidence supporting an essential role for integrin/basement membrane interaction in the RPE. Further, this report demonstrates a direct link between integrin alpha1beta1 function in retinal pigment epithelial and molecular defects in photoreceptor cell function before retinal abnormality is apparent.
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