Poly(ADP-Ribose)Polymerase Inhibition Counteracts Cataract Formation and Early Retinal Changes in Streptozotocin-Diabetic Rats
Investigative Ophthalmology & Visual Science2009Vol. 50(4), pp. 1778–1778
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Viktor R. Drel, Weizheng Xu, Jie Zhang, Peter F. Kador, Tayyeba K. Ali, Jeho Shin, Ulrich Julius, Barbara S. Slusher, Azza B. El‐Remessy, Irina G. Obrosova
Abstract
PARP activation is implicated in the formation of diabetic cataract and in early retinal changes. These findings provide a rationale for the development of PARP inhibitors for the prevention of diabetic ocular complications.
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