A Targeted Inhibitor of the Alternative Complement Pathway Reduces Angiogenesis in a Mouse Model of Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science2009Vol. 50(7), pp. 3056–3056
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Ba ̈rbel Rohrer, Qin Long, Beth Coughlin, Robert B. Wilson, Yuxiang Huang, Fei Qiao, Peter H. Tang, Kannan Kunchithapautham, Gary S. Gilkeson, Stephen Tomlinson
Abstract
Specific inhibition of the AP reduces angiogenesis in mouse CNV. Of note, intravenous injection of C3d-targeted CR2-fH is protective even though endogenous fH is present in serum at a higher relative concentration, and serum fH contains native C3d and cell surface binding domains that target it to cell surfaces. The most common AMD-associated variant of fH resides within a native cell-binding region of fH (Tyr402His). These data may open new avenues for AMD treatment strategies.
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