Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome
Investigative Ophthalmology & Visual Science2009Vol. 50(7), pp. 3203–3203
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Suksri Chotikavanich, Cintia S. de Paiva, De Quan Li, Joseph J. Chen, Fang Bian, William J. Farley, Stephen C. Pflugfelder
Abstract
Tear MMP-9 activity was significantly higher in patients with DTS. This activity was associated with increased mRNA expression of MMP-9 and its regulating genes and correlated strongly with clinical parameters. MMP-9 appears to be a potentially useful biomarker for diagnosing, classifying, and monitoring DTS.
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