T-Cell Suppression by Programmed Cell Death 1 Ligand 1 on Retinal Pigment Epithelium during Inflammatory Conditions
Investigative Ophthalmology & Visual Science2009Vol. 50(6), pp. 2862–2862
Citations Over TimeTop 10% of 2009 papers
Sunao Sugita, Yoshihiko Usui, Junko Hori, Yuri Futagami, Hiroyuki Aburatani, Taku Okazaki, Tasuku Honjo, Masaru Takeuchi, Manabu Mochizuki
Abstract
Suppression of T-cell activation was obtained in cultures only when RPE expressed negative costimulators. Therefore, the authors propose that in vitro, Th1 cytokine-exposed ocular resident cells can express this molecule and it is this expression that causes the suppression of the bystander Th1-type cells.
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