Localization of Age-Related Macular Degeneration-Associated ARMS2 in Cytosol, Not Mitochondria
Investigative Ophthalmology & Visual Science2009Vol. 50(7), pp. 3084–3084
Citations Over TimeTop 10% of 2009 papers
Gaofeng Wang, Kylee L. Spencer, Brenda L. Court, Lana M. Olson, William K. Scott, Jonathan L. Haines, Margaret A. Pericak‐Vance
Abstract
The significant associations in ARMS2 and HTRA1 are with polymorphisms in strong LD that confer virtually identical risks, preventing differentiation at the statistical level. ARMS2 was mainly distributed in the cytosol, not in the mitochondrial outer membrane as previously reported, suggesting that ARMS2 may not confer risk to AMD through the mitochondrial pathway.
Related Papers
- → Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans(2003)317 cited
- Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.(2012)
- → Predicting late-stage age-related macular degeneration by integrating marginally weak SNPs in GWA studies(2023)7 cited
- → Genome-wide linkage disequilibrium in South African abalone, Haliotis midae, and implications for understanding complex traits(2020)6 cited
- Analysis of perforin and granzyme B gene single nucleotide polymorphisms in Han population of Chongqing.(2010)