Endogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-β-Synthase Mutant Mouse
Investigative Ophthalmology & Visual Science2009Vol. 50(9), pp. 4460–4460
Citations Over TimeTop 11% of 2009 papers
Preethi S. Ganapathy, Brent Moister, Penny Roon, Barbara A. Mysona, Jennifer Duplantier, Ying Dun, Tracy K. V. E. Moister, Marlena J. Farley, Puttur D. Prasad, Kebin Liu, Sylvia B. Smith
Abstract
This study provides the first analysis of morphologic and molecular effects of endogenous elevations of retinal homocysteine in an in vivo model. Increased retinal homocysteine alters inner and outer retinal layers in cbs homozygous mice and older cbs heterozygous mice, and it primarily affects the cells of the GCL in younger heterozygous mice. Elevated retinal homocysteine alters expression of genes involved in endoplasmic reticular stress, N-methyl-d-aspartate (NMDA) receptor activation, cell cycle, and apoptosis.
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