The Drusenlike Phenotype in AgingCcl2-Knockout Mice Is Caused by an Accelerated Accumulation of Swollen Autofluorescent Subretinal Macrophages
Investigative Ophthalmology & Visual Science2009Vol. 50(12), pp. 5934–5934
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Ulrich F. O. Luhmann, Scott Robbie, Peter Munro, Susie E. Barker, Yanaí Durán, Vy Luong, F.W. Fitzke, James Bainbridge, Robin R. Ali, Robert E. MacLaren
Abstract
These findings suggest that the lack of Ccl2 leads to a monocyte/macrophage-trafficking defect during aging and to an impaired recruitment of these cells to sites of laser injury. Other, previously described features of Ccl2(-/-) mice that are similar to AMD may be the result of aging alone.
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