ERK- and Akt-Dependent Neuroprotection by Erythropoietin (EPO) against Glyoxal-AGEs via Modulation of Bcl-xL, Bax, and BAD
Investigative Ophthalmology & Visual Science2010Vol. 51(1), pp. 35–35
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Jianfeng Shen, Yalan Wu, Jingying Xu, Jingfa Zhang, Stephen H. Sinclair, Myron Yanoff, Guoxu Xu, Weiye Li, Guo‐Tong Xu
Abstract
These data demonstrate that exogenous EPO significantly attenuates the retinal neuronal cell death induced by glyoxal-AGEs by promoting antiapoptotic and suppressing apoptotic proteins. EPO/EPO receptor signaling through ERK and Akt pathways is pivotal in EPO neuroprotective mechanisms.
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