Nanoscale Topography–Induced Modulation of Fundamental Cell Behaviors of Rabbit Corneal Keratocytes, Fibroblasts, and Myofibroblasts
Investigative Ophthalmology & Visual Science2010Vol. 51(3), pp. 1373–1373
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Simon A. Pot, Sara J. Liliensiek, Kathern E. Myrna, Ellison Bentley, James V. Jester, Paul F. Nealey, Christopher J. Murphy
Abstract
Corneal stromal cells elongated, aligned, and migrated, differentially guided by substratum topographic features. All cell types failed to respond to topographic features approximating the dimensions of individual stromal fibers. These findings contribute to our understanding of corneal stromal cell biology in health and disease and their interaction with biomaterials and their native extracellular matrix.
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