Three Gene-Targeted Mouse Models of RNA Splicing Factor RP Show Late-Onset RPE and Retinal Degeneration
Investigative Ophthalmology & Visual Science2010Vol. 52(1), pp. 190–190
Citations Over TimeTop 19% of 2010 papers
John J. Graziotto, Michael H. Farkas, Kinga M. Bujakowska, Bertrand M.J.‐M. Deramaudt, Qí Zhāng, Emeline F. Nandrot, Chris F. Inglehearn, Shomi S. Bhattacharya, Eric A. Pierce
Abstract
The finding of similar degenerative changes in RPE cells of all three mouse models suggests that the RPE may be the primary cell type affected in the RNA splicing factor forms of RP. The relatively late-onset phenotype observed in these mice is consistent with the typical adult onset of disease in patients with RP.
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