Epigenetics, MicroRNAs, and Carcinogenesis: Functional Role of MicroRNA-137 in Uveal Melanoma
Investigative Ophthalmology & Visual Science2010Vol. 52(3), pp. 1193–1193
Citations Over TimeTop 10% of 2010 papers
Xiaohong Chen, Jiao Wang, Huanjun Shen, Juan Lü, Canxia Li, Dan‐Ning Hu, Xiang Da Dong, Dongsheng Yan, Lili Tu
Abstract
The results showed that miR-137 can act as a tumor suppressor in uveal melanoma cell proliferation through downregulation of the targets MITF and CDK6. miR-137 may be epigenetically silenced during uveal melanoma tumorigenesis.
Related Papers
- Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.(1995)
- → Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.(1995)963 cited
- → Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.(1994)726 cited
- [Cyclin-dependent kinase inhibitors in mammal cells].(1996)
- The Role of Cell Cycle Regulators in Normal and Malignant Cell Proliferation(2010)