TGF-β Induces Sustained Upregulation of SNAI1 and SNAI2 through Smad and Non-Smad Pathways in a Human Corneal Epithelial Cell Line
Investigative Ophthalmology & Visual Science2010Vol. 52(5), pp. 2437–2437
Citations Over TimeTop 22% of 2010 papers
Keiichi Aomatsu, Tokuzo Arao, Koji Sugioka, Kunio Matsumoto, Daisuke Tamura, Kanae Kudo, Hiroyasu Kaneda, Kaoru Tanaka, Yoshihiko Fujita, Yoshikazu Shimomura, Kazuto Nishio
Abstract
TGF-β induces sustained upregulation of SNAI1 and SNAI2 through Smad and non-Smad pathways, EMT-like morphologic changes, downregulation of E-cadherin, and upregulation of N-cadherin in HCECs. The authors' findings provide insight into the TGF-β signaling and the temporal expression patterns of EMT-inducible transcription factors in HCECs.
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