ADAMTSL4, a Secreted Glycoprotein Widely Distributed in the Eye, Binds Fibrillin-1 Microfibrils and Accelerates Microfibril Biogenesis
Investigative Ophthalmology & Visual Science2011Vol. 53(1), pp. 461–461
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Luís Alexandre Rassi Gabriel, Lauren W. Wang, Hannah L. Bader, Jason Ho, Alana K. Majors, Joe G. Hollyfield, Elias I. Traboulsi, Suneel Apte
Abstract
ADAMTSL4 is a secreted glycoprotein that is widely distributed in the human eye. Enhanced fibrillin-1 deposition in the presence of ADAMTSL4 and colocalization of ADAMTSL4 with fibrillin-1 in the ECM of cultured fibroblasts suggest a potential role for ADAMTSL4 in the formation or maintenance of the zonule.
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