Effect of Brimonidine on Retinal and Choroidal Neovascularization in a Mouse Model of Retinopathy of Prematurity and Laser-Treated Rats
Investigative Ophthalmology & Visual Science2011Vol. 52(8), pp. 5424–5424
Citations Over TimeTop 19% of 2011 papers
Jyotirmoy Kusari, E. Padillo, Sheila Zhou, Yanyan Bai, Juanjuan Wang, Zhiming Song, Meili Zhu, Yun-Zheng Le, Daniel W. Gil
Abstract
BRI treatment significantly attenuated vitreoretinal VEGF concentrations, retinal vascular leakage, and retinal and choroidal neovascularization in animal models of ROP and CNV. BRI may inhibit underlying event(s) of ischemia responsible for upregulation of vitreoretinal VEGF and thus reduce vascular leakage and retinal-choroidal neovascularization.
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