Multiplex Ligation-Dependent Probe Amplification of Conjunctival Melanoma Reveals CommonBRAFV600E Gene Mutation and Gene Copy Number Changes
Investigative Ophthalmology & Visual Science2011Vol. 52(8), pp. 5598–5598
Citations Over TimeTop 10% of 2011 papers
Abstract
No copy number changes were associated exclusively with metastatic CoMs. However, further investigation of the role of CDKN1A and RUNX2 in CoMs development and that of MLH1, TIMP2, MGMT, and ECHS1 in metastatic CoMs is warranted. Validation of the observed gene and chromosome arm copy number changes in a larger cohort of primary and metastatic CoMs is necessary to identify the patients at highest risk for CoMs metastasis.
Related Papers
- → Role of BRAF‐V600E in the serrated pathway of colorectal tumourigenesis(2007)92 cited
- → Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions(2008)23 cited
- → Investigation of copy number variation in children with conotruncal heart defects(2014)22 cited
- → Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online.(1998)48 cited
- Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions(2008)