Multiphoton Microscopy of Ex Vivo Corneas after Collagen Cross-Linking
Investigative Ophthalmology & Visual Science2011Vol. 52(8), pp. 5325–5325
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Juan M. Bueno, Emilio J. Gualda, Anastasia Giakoumaki, Pablo Pérez‐Merino, Susana Marcos, Pablo Artal
Abstract
Nonlinear microscopy (in both tomographic and regular XY imaging configurations) was used to study spatial and temporal changes in the cornea during and after CXL on intact ocular globes. SHG imaging showed changes in the morphology of anterior corneal stroma after CXL. Regular collagen patterns turned into random distributed structures with thicker bundles at some localized areas. This might be a consequence of the corneal thickness decrease as a result of riboflavin-dextran instillation.
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