Normoxic Activation of Hypoxia-Inducible Factors in Photoreceptors Provides Transient Protection against Light-Induced Retinal Degeneration
Investigative Ophthalmology & Visual Science2011Vol. 52(8), pp. 5872–5872
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Christina Lange, Severin R. Heynen, Naoyuki Tanimoto, Markus Thiersch, Yun‐Zheng Le, Isabelle Meneau, Mathias W. Seeliger, Marijana Samardzija, Christian Caprara, Christian Grimm
Abstract
Artificial activation of HIF transcription factors in normoxic photoreceptors results in an increased basal expression of Fgf2 that may contribute to a transient protection of rods against light damage. Full photoreceptor protection may require a hypoxia-like response in additional retinal cell types and/or the differential regulation of additional mechanisms.
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