WDR36andP53Gene Variants and Susceptibility to Primary Open-Angle Glaucoma: Analysis of Gene-Gene Interactions
Investigative Ophthalmology & Visual Science2011Vol. 52(11), pp. 8467–8467
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Cristina Blanco-Marchite, Francisco Sánchez‐Sánchez, María-Pilar López-Garrido, Mercedes Iñigez-de-Onzoño, Francisco López-Martínez, E. López-Sánchez, Lydia Álvarez, Pedro-Pablo Rodríguez-Calvo, Carmen Méndez-Hernández, Luís Fernández-Vega, J. García–Sánchez, Miguel Coca‐Prados, Julián García-Feijoo, Julio Escribano
Abstract
Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma risk factors in Spanish patients. The authors provide evidence for a genetic interaction between WDR36 and P53 variants in POAG susceptibility, although this finding must be confirmed in other populations.
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