Larger Therapeutic Window for Steroid versus VEGF-A Inhibitor in Inflammatory Angiogenesis: Surprisingly Similar Impact on Leukocyte Infiltration
Investigative Ophthalmology & Visual Science2012Vol. 53(7), pp. 3296–3296
Citations Over TimeTop 10% of 2012 papers
Shintaro Nakao, Souska Zandi, Nuria Lara-Castillo, Mahdi Taher, Tatsuro Ishibashi, Ali Hafezi‐Moghadam
Abstract
VEGF-A inhibition affected angiogenic sprouting, while it was not effective against matured vessels. Both dexamethasone and bevacizumab inhibited leukocyte transmigration from angiogenic vessels; however, dexamethasone had a larger therapeutic window. These insights improve the treatment strategy in angiogenic disorders.
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