GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy
Investigative Ophthalmology & Visual Science2012Vol. 53(4), pp. 2208–2208
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Deeksha Gambhir, Sudha Ananth, Rajalakshmi Veeranan‐Karmegam, Selvakumar Elangovan, Shanterian Hester, Eric Jennings, Stefan Offermanns, Julian J. Nussbaum, Sylvia B. Smith, Muthusamy Thangaraju, Vadivel Ganapathy, Pamela M. Martin
Abstract
GPR109A plays an anti-inflammatory role in RPE and its expression is upregulated in diabetes. Inflammation is a key causative factor in the pathogenesis of diabetic retinopathy. We speculate that the increased expression of GPR109A and elevation of its ligand β-HB in diabetes are mechanisms by which the tissue attempts to fight inflammation in this disease. Pharmacological activation of GPR109A may therefore have therapeutic potential in clinical management of diabetic retinopathy.
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