Generation of an Inbred Miniature Pig Model of Retinitis Pigmentosa
Investigative Ophthalmology & Visual Science2012Vol. 53(1), pp. 501–501
Citations Over TimeTop 10% of 2012 papers
Jason W. Ross, Juan P. Fernandez de Castro, Jianguo Zhao, Melissa Samuel, Eric M. Walters, Cecilia Rios, Patricia Bray‐Ward, Bryan W. Jones, Robert E. Marc, Wei Wang, Liang Zhou, Jennifer Noel, Maureen A. McCall, Paul J. DeMarco, Randall S. Prather, Henry J. Kaplan
Abstract
Expression of the human RHO P23H transgene in the retina creates a miniature swine model with an inheritance pattern and retinal function that mimics adRP. This large-animal model can serve as a novel tool for the study of the pathogenesis and therapeutic intervention in the most common form of adRP.
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