Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma
Investigative Ophthalmology & Visual Science2012Vol. 53(3), pp. 1557–1557
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Gulab Zode, Kevin Bugge, Kabhilan Mohan, Siniša D. Grozdanić, Joseph C. Peters, Demelza Koehn, Michael G. Anderson, Randy H. Kardon, Edwin M. Stone, Val C. Sheffield
Abstract
Topical ocular PBA reduces glaucomatous phenotypes in Tg-MYOC(Y437H) mice, most likely by reducing myocilin accumulation and ER stress in the TM. Topical ocular PBA could become a novel treatment for POAG patients with myocilin mutations.
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