An ENU Mutagenesis Screen in Zebrafish for Visual System Mutants Identifies a Novel Splice-Acceptor Site Mutation inpatched2that Results in Colobomas
Investigative Ophthalmology & Visual Science2012Vol. 53(13), pp. 8214–8214
Citations Over TimeTop 23% of 2012 papers
Jiwoon Lee, Ben D. Cox, Christina M. Daly, Chanjae Lee, Richard J. Nuckels, Rachel K. Tittle, Rosa A. Uribe, Jeffrey M. Gross
Abstract
We have identified 18 recessive mutations affecting development of the zebrafish visual system and we have characterized a novel splice-acceptor site mutation in patched2 that results in enhanced Hh pathway activity and colobomas.
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