Subretinal Implantation of Retinal Pigment Epithelial Cells Derived From Human Embryonic Stem Cells: Improved Survival When Implanted as a Monolayer
Investigative Ophthalmology & Visual Science2013Vol. 54(7), pp. 5087–5087
Citations Over TimeTop 10% of 2013 papers
Bruno Diniz, Padmaja B. Thomas, Biju B. Thomas, Ramiro Ribeiro, Yuntao Hu, Rodrigo Brant, Ashish Ahuja, Danhong Zhu, Laura Liu, Michael Koss, Maurício Maia, Gerald J. Chader, David R. Hinton, Mark S. Humayun
Abstract
hESC-RPE can survive for at least 12 months in an immunocompromised animal model. Polarized monolayers of hESC-RPE show improved survival compared to cell suspensions. The lack of teratoma or any ectopic tissue formation in the implanted rats bodes well for similar results with respect to safety in human subjects.
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