Quantitative Analysis of Tear Film Fluorescence and Discomfort During Tear Film Instability and Thinning
Investigative Ophthalmology & Visual Science2013Vol. 54(4), pp. 2645–2645
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Abstract
Concentration quenching of fluorescein dye with tear film thinning best explains decreasing tear film fluorescence during trials. This was highly correlated with increasing ocular discomfort, suggesting that both tear film thinning and TBU stimulate underlying corneal nerves, although TBU produced more rapid stimulation. Slow increases in tear film hyperosmolarity may cause the gradual increase in discomfort during slow tear film thinning, whereas the sharp increases in discomfort during TBU suggest a more complex stimulus.
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