Antiapoptotic Properties of α-Crystallin–Derived Peptide Chaperones and Characterization of Their Uptake Transporters in Human RPE Cells
Investigative Ophthalmology & Visual Science2013Vol. 54(4), pp. 2787–2787
Citations Over TimeTop 10% of 2013 papers
Parameswaran G. Sreekumar, Paresh P. Chothe, K. Krishna Sharma, Rinku Baid, Uday B. Kompella, Christine Spee, Nandini Kannan, Christina Manh, Stephen J. Ryan, Vadivel Ganapathy, Ram Kannan, David R. Hinton
Abstract
αA- and αB-crystallin mini-chaperones offer protection to hfRPE cells and inhibit caspase-3 activation. The oligopeptide transporters SOPT1 and SOPT2 mediate the uptake of these peptides in RPE cells. Nanodelivery of αB-crystallin-derived mini-chaperone peptide offers an alternative approach for protection of hfRPE cells from oxidant injury.
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