Activation of the Alternative Complement Pathway in Vitreous is Controlled by Genetics in Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science2012Vol. 53(10), pp. 6628–6628
Citations Over TimeTop 10% of 2012 papers
Kelly M. Loyet, Laura DeForge, Kenneth J. Katschke, Lauri Diehl, Robert Graham, Lily Pao, Lizette Sturgeon, Sock-Cheng Lewin-Koh, Joe G. Hollyfield, Menno van Lookeren Campagne
Abstract
Increased activation of the alternative complement pathway in vitreous was controlled by disease stage and genetic variation in the complement pathway, supporting a role for complement activation in AMD disease pathogenesis.
Related Papers
- → Systemic Complement Activation in Age-Related Macular Degeneration(2008)359 cited
- → Interaction of Vaccinia Virus Complement Control Protein with Human Complement Proteins: Factor I-Mediated Degradation of C3b to iC3b1 Inactivates the Alternative Complement Pathway(1998)147 cited
- → The Functional Effect of Rare Variants in Complement Genes on C3b Degradation in Patients With Age-Related Macular Degeneration(2016)54 cited
- Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.(2012)
- → Genotype‐phenotype correlations of low‐frequency variants in the complement system in renal disease and age‐related macular degeneration(2018)23 cited