Fundus Autofluorescence in theAbca4−/−Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and Histology
Investigative Ophthalmology & Visual Science2013Vol. 54(8), pp. 5602–5602
Citations Over TimeTop 10% of 2013 papers
Peter Charbel Issa, Alun R. Barnard, Mandeep S. Singh, Emma Carter, Zhichun Jiang, Roxana A. Radu, Ulrich Schraermeyer, Robert E. MacLaren
Abstract
Fundus AF can be used to monitor lipofuscin accumulation and melanin-related changes in vivo in mouse models of retinal disease. High RPE lipofuscin may not adversely affect retinal structure or function over prolonged time intervals, and melanin-related changes (melanolipofuscin formation) may occur before the decline in retinal function.
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