Functional Analysis of Serially Expanded Human iPS Cell-Derived RPE Cultures
Investigative Ophthalmology & Visual Science2013Vol. 54(10), pp. 6767–6767
Citations Over TimeTop 10% of 2013 papers
Ruchira Singh, M. Joseph Phillips, David Kuai, Jackelyn Meyer, Jessica Martin, Molly A. Smith, Enio T. Perez, Wei Shen, Kyle A. Wallace, Elizabeth E. Capowski, Lynda S. Wright, David M. Gamm
Abstract
Highly differentiated, pigmented hiPSC-RPE monolayers can undergo limited serial expansion while retaining key cytological and functional attributes. However, passaging hiPSC-RPE cultures beyond senescence leads to loss of such features. Our findings support limited, controlled passaging of patient-specific hiPSC-RPE to procure cells needed for in vitro disease modeling, drug screening, and cellular transplantation.
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