TLR-Independent and P2X7-Dependent Signaling MediateAluRNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy
Investigative Ophthalmology & Visual Science2013Vol. 54(12), pp. 7395–7395
Citations Over TimeTop 10% of 2013 papers
Nagaraj Kerur, Yoshio Hirano, Valeria Tarallo, Benjamin J. Fowler, Ana Bastos-Carvalho, Tetsuhiro Yasuma, Reo Yasuma, Young‐Hee Kim, David R. Hinton, Carsten J. Kirschning, Bradley D. Gelfand, Jayakrishna Ambati
Abstract
NF-κB and P2X7 are critical signaling intermediates in Alu RNA-induced inflammasome priming and RPE degeneration. These molecules are novel targets for rational drug development for geographic atrophy.
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